You don't appear to have understood the question. You said it seemed certain that the McCanns 'raised the issue of sedatives being used on the children with the UK police on the 5th May'.
What made you certain that they did that?
The first two FLO that arrive both report this
e.g.
http://www.mccannpjfiles.co.uk/PJ/STEPHEN_MARKLEY.htm "However, in relation to the above, I would like to add the following: At about 20.00 on Saturday 5th May 2007, I arrived at the apartment where Kate and Gerry were staying, with other officers. During the meeting Gerald and Kate had a number of questions to which they wanted follow up and responses from the PJ.
One of these questions was that they wanted the PJ to be aware of was Madeleine's revelation about Wednesday night, when she said that she was left alone during the night. She told Kate and Gerry that she remembered the twins crying and that she wanted to know why neither her mother nor her father had gone to the room to see what was happening.
They also wanted to know whether the PJ had any evidence that would suggest that the person who took Madeleine had used any substance to facilitate the abduction."
http://www.mccannpjfiles.co.uk/PJ/JIM_McGARVEY.htm was the other.