The reason I ask is, the twins slept heavily throughout the mayhem in the apartment that night, but when they were woken to go to another apartment they did not display any ill-effects ... would that be normal ?
I think they didn't wake up when they were carried to another flat. Many found it strange, but likely found it was better this way. I've never seen comment about the way they woke up the following morning.
KM n her book says at first light she and GM went out searching for at least an hour and on their return to FPs flat the twins were up and about playing
In answer to the OP, its entirely probably that Madeleine might be sedated if she was taken, even by car, for sure if being carried around the streets of PDL, and especially if an hour or so later than the assumed 9.15 time
I do not think that any abductor would do any dry run and sedate her the night before, neither makes sense, and even less, someone doing this on the Thursday during the day
I also do not believe the twins were sedated by any abdudtor, there would be no point JMHO
Certainly certain questions arise, one being why, in KMs own words she was checking the twins for signs of life and thnkng they had been drugged did she not arrange for them to be taken to a hospital