To be more precise, apart from the fact of Madeleine's disappearance, there is no evidence of anything.
Unless there is the proverbial bolt from the blue, such as a confession, nothing is like to change.
There is virtually no evidence of anything, no.
As to your second statement, this is where we all have to keep an open mind. I actually think that there is a very good chance that we could learn more about what happened. That's not to say we'll get to the bottom of things. But between developing technologies in forensics and the persistence with which the McCanns and others are holding on to this case, there is a good chance someone is going to discover something somewhere along the line.
There is also the matter of shifting loyalties. Someone who may have been quiet for whatever reason could decide to come forward in time, as circumstances change.
The smallest piece of information or evidence can change our entire understanding.