OK Maybe not a true translation but the source, for the questions had to be agreed upon. Well that is how I conceptualize it ATM.
The Portuguese ask a question relating to sedation and it get watered down to the question on the note.
"* Was there anything said or done by KATE or GERALD McCANN in your presence or during any contact with them that raised any suspicion that they had any knowledge of what had happened to MADELEINE other than that of the circumstances described to this Portuguese Investigation ?)"
Page 120 http://www.mccannpjfiles.co.uk/PJ/RESPONSE-ROGATORY.htm#rr20
The answers to the original questions would have allowed the Portuguese to discover exactly what was said to the liaison officers by the McCanns.
The answers to the replacement question allowed the Portuguese to find out what was said only if the liaison officers thought it was suspicious.
In the UK part of these officer's job is to gather information for the investigation. I expect they use their judgement about what to pass on, though. If Kate and Gerry were calling for the twins to be tested the officers may have seen this as an over-reaction by two worried parents and not passed it on. At the time they had no way of knowing what a huge issue it would become, of course. .
The replacement question allowed them to say 'No' even if the McCann's did ask for the twins to be tested, because in their opinion it wasn't suspicious for them to do so.
The two officers who said 'No' to the replacement question, then added something, may have been speaking in hindsight. i.e. they didn't find what the McCanns said suspicious at the time, but may have wondered about it subsequently.