Actually, in the case of the Needhams and Barry George, there is NO evidence implicating them. The same can't be said of the McCann case imo.
In my opinion there is nothing which Amaral used as evidence which implicates them from "The Badly Told Story" to Calpol being a sedative to the dogs to the misinterpreted forensic results.
But the prosecutors hit the nail bang on the head when they continued ...
Even if, hypothetically, one could admit that Gerald and Kate McCann might be responsible over the child's death, it would still have to be explained how, where through, when, with what means, with the help of whom and where to they freed themselves of her body within the restricted time frame that would have been available to them to do so.
Their daily routine, until the 3rd of May, had been circumscribed to the narrow borders of the 'Ocean Club' resort and to the beach that lies next to it, unknowing the surrounding terrain and, apart from the English friends that were with them on holiday there, they had no known friends or contacts in Portugal.Unsurprisingly Amaral could not come up with an answer to that one. And over the past thirteen+ years neither could anyone else for the simple reason there is no evidence against Gerry and Kate whatsoever.