If the children were being sedated...

[ferryman]

Sourced elsewhere. In reference to Calpol.

Noting, in the article it does state,Calpol is not to be given to children under the age of 6.
---------------------------------------------------------------------

CALPOL NIGHT WHICH WAS NOT TAKEN OFF THE MARKET UNTIL 2009

Calpol night oral solution contains two active ingredients, paracetamol and diphenhydramine hydrochloride.

Paracetamol is a simple painkilling medicine used to relieve mild to moderate pain and fever. Despite its widespread use for over 100 years, we still don't fully understand how paracetamol works to relieve pain and reduce fever. However, it is now thought that it works by reducing the production of prostaglandins in the brain and spinal cord.

The body produces prostaglandins in response to injury and certain diseases. One of the effects of prostaglandins is to sensitise nerve endings, causing pain (presumably to prevent us from causing further harm to the area). As paracetamol reduces the production of these nerve sensitising prostaglandins it is thought it may increase our pain threshold, so that although the cause of the pain remains, we can feel it less.

It is thought paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center).

Diphenhydramine is a type of medicine called a sedating antihistamine. It enters the brain in sufficient quantities to cause drowsiness.

Read more: http://www.netdoctor.co.uk/aches-and-pains/medicines/calpol-night.html#ixzz2yylJzAbh
Follow us: @NetDoctor on Twitter | NetDoctorUK on Facebook

Ah.

The key point is not when it was withdrawn, but when it was introduced, just about the time the |McCanns were made arguidos.

Branding: Calpol expands kids' remedies
12.09.2007


 
inShare
Children's medicine brand Calpol is broadening its range with the addition of three variants.
The brand, which is owned by Pfizer Consumer Healthcare, is rolling out Calpol Night, a pain-relief medicine; CalCough, a cough remedy, which comes in Chesty and Tickly variants, and CalCold, which relieves cold and flu symptoms in children aged three months and over. It is also introducing a Calpol Vapour Plug & Nightlight.

The launch of the products, which will be available from this month, will be backed by a marketing and PR campaign.

In the year to June 2007, Calpol had a 60% share of the children's pain and fever relief category, according to IRI.

Pfizer hopes that the additional products will grow its share of the children's medicines market by 4.5% in 2008, which would equate to an extra £6.5m in sales.

If Madeleine has ever, in her life, been given the drug, that would have been by her abductor.

[John]

Perhaps you could point out when Calpol Night first appeared on the market and where it has been established that the McCanns had it with them.

The McCanns detailed in their statements which medications they carried on holiday to Portugal and Calpol was among them.  If Gerry could get his hands on Terfenadine after it had been removed from the list of prescribed drugs in the UK he...

[sadie]

The McCanns detailed in their statements which medications they carried on holiday to Portugal and Calpol was among them.  If Gerry could get his hands on Terfenadine after it had been removed from the list of prescribed drugs in the UK he...

he what, John?

[stephen25000]

Ah.

The key point is not when it was withdrawn, but when it was introduced, just about the time the |McCanns were made arguidos.

Branding: Calpol expands kids' remedies
12.09.2007


 
inShare
Children's medicine brand Calpol is broadening its range with the addition of three variants.
The brand, which is owned by Pfizer Consumer Healthcare, is rolling out Calpol Night, a pain-relief medicine; CalCough, a cough remedy, which comes in Chesty and Tickly variants, and CalCold, which relieves cold and flu symptoms in children aged three months and over. It is also introducing a Calpol Vapour Plug & Nightlight.

The launch of the products, which will be available from this month, will be backed by a marketing and PR campaign.

In the year to June 2007, Calpol had a 60% share of the children's pain and fever relief category, according to IRI.

Pfizer hopes that the additional products will grow its share of the children's medicines market by 4.5% in 2008, which would equate to an extra £6.5m in sales.

If Madeleine has ever, in her life, been given the drug, that would have been by her abductor.

I shall await the reply from Johnson and Johnson.

[Cudge]

Looks like somebody has already been down that route


Our Ref: XXXXXX-Letter
Date: XXXX 2009


Dear Madam/Sir

Thank you for your recent enquiry concerning Calpol Infant Suspension (120mg paracetamol per 5ml).

Calpol Infant Suspension contains paracetamol which is used to relieve pain and reduce fever. As you rightly point out, it does not have sedative properties. We are keen to ensure that consumers understand how to use all of our products correctly. In the case of Calpol, we ensure clear messages in our advertising to ensure correct usage. The product also contains clear instructions for use on the box and within the enclosed patient information leaflet.

Thank you for your concern regarding the reputation of our product and the suggestion that we contact Mr Amaral. We will give your suggestion due consideration.


Yours sincerely

Johnson & Johnson Ltd

XXXXXX XXXXXXXX BSc (Hons)
Medical Information Officer
Professional Information Ltd
on behalf of Johnson & Johnson Ltd

[stephen25000]

Looks like somebody has already been down that route


Our Ref: XXXXXX-Letter
Date: XXXX 2009


Dear Madam/Sir

Thank you for your recent enquiry concerning Calpol Infant Suspension (120mg paracetamol per 5ml).

Calpol Infant Suspension contains paracetamol which is used to relieve pain and reduce fever. As you rightly point out, it does not have sedative properties. We are keen to ensure that consumers understand how to use all of our products correctly. In the case of Calpol, we ensure clear messages in our advertising to ensure correct usage. The product also contains clear instructions for use on the box and within the enclosed patient information leaflet.

Thank you for your concern regarding the reputation of our product and the suggestion that we contact Mr Amaral. We will give your suggestion due consideration.


Yours sincerely

Johnson & Johnson Ltd

XXXXXX XXXXXXXX BSc (Hons)
Medical Information Officer
Professional Information Ltd
on behalf of Johnson & Johnson Ltd

For Calpol night ?

For reference purposes:

http://www.medicines.org.uk/emc/medicine/18986/SPC/Calpol+Infant+Suspension

http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con014180.pdf

[Jean-Pierre]

Stephen.  I am not quite sure why you are banging on about calpol night.   I am sure you find it terribly interesting, but it really is irrelevant to the discussion in hand as it was not released until September 2007. 

The McCanns had a medication called Calpol.  Now I think called Calpol Infant Suspension.  And it is OK for children over 6 months old. 

[gilet]

The McCanns detailed in their statements which medications they carried on holiday to Portugal and Calpol was among them.  If Gerry could get his hands on Terfenadine after it had been removed from the list of prescribed drugs in the UK he...

But it was not banned from being prescribed in the UK. It was perfectly legal to prescribe terfenadine to adults in the UK (and I believe may well still be).

As for Calpol night, would you go as far as suggesting that it was illegally given to Gerry or Kate by the company prior to its being permitted in the UK? If so, I would be wary of a libel action from that company.

[gilet]

For Calpol night ?

For reference purposes:

http://www.medicines.org.uk/emc/medicine/18986/SPC/Calpol+Infant+Suspension

http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con014180.pdf

Unless you are intending this to be a libel on the company which produced Calpol Night and are inferring that it was released to Gerry and Kate before official permission was granted in mid 2007 for it to be used in the UK then I suggest you make your point clear.

Calpol night was not released in the UK till September 2007.

Your posts are as usual rather irrelevant because you either do now wish to learn the facts about the matter or are deliberatly trying to disrupt.

[stephen25000]

Unless you are intending this to be a libel on the company which produced Calpol Night and are inferring that it was released to Gerry and Kate before official permission was granted in mid 2007 for it to be used in the UK then I suggest you make your point clear.

Calpol night was not released in the UK till September 2007.

Your posts are as usual rather irrelevant because you either do now wish to learn the facts about the matter or are deliberatly trying to disrupt.

Incorrect.

The marketing authorisation in UK for Calpol Night was granted on 12th Jan 2007.

A variation on the PSUR Reporting Period was granted on the 15/07/2007 from 6 months to 3 years.


http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con014180.pdf


It is you who needs to learn the facts and as you didn't even provide a source for your statement, what does that make you ?

I may have more to add to this , if and when I receive a reply from the company concerned.

P.S. At this point I am trying to ascertain when samples of the product where being tested prior to release of the product to the general public.

[sadie]

Madeleine especially was extraordinarily tired that afternoon / evening.  She was so tired that The Mccanns had to carry her back from the Tapas at about 5.30pm IIRC

All three children were too tired to play on the slide and climbing frame thingy, as usual, before bed on May 3rd.  It seems it was the norm for all the Tapas group kiddies to be have their tea at the Tapas, have their baths, get their jamies on then meet outside for a short play together on the tapas kiddie stuff.  I bet thta was the highlight of their day... but they were just too tired  >@@(*&)

Why were they too tired that night?  I have always felt that someone at the Tapas restaurant slipped a sedative / sleeping draught into their hot chocolate or in a sandwich ... whatever.

I simply cannot understand the tiredness of all three of them .. but especially Madeleine... so tired thta she had to be carried home.    Maybe a double dose given to her hidden in her drink?  Dunno

The twins slept very deeply that night too. >@@(*&)

[Carew]

Madeleine especially was extraordinarily tired that afternoon / evening.  She was so tired that The Mccanns had to carry her back from the Tapas at about 5.30pm IIRC

All three children were too tired to play on the slide and climbing frame thingy, as usual, before bed on May 3rd.  It seems it was the norm for all the Tapas group kiddies to be have their tea at the Tapas, have their baths, get their jamies on then meet outside for a short play together on the tapas kiddie stuff.  I bet thta was the highlight of their day... but they were just too tired  >@@(*&)

Why were they too tired that night?  I have always felt that someone at the Tapas restaurant slipped a sedative / sleeping draught into their hot chocolate or in a sandwich ... whatever.
field`s baby
I simply cannot understand the tiredness of all three of them .. but especially Madeleine... so tired thta she had to be carried home.    Maybe a double dose given to her hidden in her drink?  Dunno

The twins slept very deeply that night too. >@@(*&)

Wasn`t  Dr. Oldfield`s baby ill with diarrhoea and also Dr O`Brien`s small daughter sick that evening?

Maybe the McCann children were simply feeling a bit under the weather..... Infants fight off a bug going round or react to it in different ways, don`t they?

[sadie]

Wasn`t  Dr. Oldfield`s baby ill with diarrhoea and also Dr O`Brien`s small daughter sick that evening?

Maybe the McCann children were simply feeling a bit under the weather..... Infants fight off a bug going round or react to it in different ways, don`t they?

That is true, but no indications of illness with the Mccann children have been given, so I think it unlikely tbh

Was Matts baby ill then?  I missed that.

[John]

Wasn`t  Dr. Oldfield`s baby ill with diarrhoea and also Dr O`Brien`s small daughter sick that evening?

Maybe the McCann children were simply feeling a bit under the weather..... Infants fight off a bug going round or react to it in different ways, don`t they?

This was the day of the sailing activity iirc.  No wonder Maddie was exhausted.

[Carew]

That is true, but no indications of illness with the Mccann children have been given, so I think it unlikely tbh

Was Matts baby ill then?  I missed that.

This is from Rachael`s rog....


"1578    “Okay, and when you went to check on Grace, what sort of checks would you conduct”?
Reply    “Erm well we’d go into the room, which ordinarily we wouldn’t do to be honest, erm but she seemed to have diarrhoea and kind of, I mean she’d settled quite well actually cos she’d been tired every evening, erm but every morning when she woke up, she had diarrhoea and it had gone right through her grow bag and so there’s all of this sort of horrendous smell, so in the evenings when we were checking, we’d go into the room just to see if you know, there was any sort of smell yet, erm and just to make sure she was alright, to make sure she hadn’t been sick, partly I think cos Matt had been sick, just wanted to make sure that she hadn’t been, in case it was some sort of bug”."